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Senior Scientist

Company: Ardelyx
Location: Fremont
Posted on: May 3, 2021

Job Description:

Ardelyx is a publicly traded biotech company focused on improving the lives of patients by developing and commercializing first-in-class targeted therapies that advance patient care. Using our discovery model, Ardelyx scientists have characterized new biological mechanisms and pathways that have enabled us to develop a pipeline of drug candidates to manage complications related to kidney and cardiovascular diseases. Our lead candidate, tenapanor, is a first-in-class small molecule therapy for the treatment of hyperphosphatemia in adult patients with chronic kidney disease on dialysis. If approved, tenapanor could completely change the treatment paradigm in a disease state with significant unmet need. We are advancing the build of our commercial organization to be prepared for launch of tenapanor in mid-2021.


We are looking for an accomplished scientist capable of using a variety of laboratory techniques to conduct PK/ADME and mechanistic studies supporting drug discovery research programs. As a member of the drug discovery team, the ideal candidate would have a thorough understanding of ADME principles and their application to drug discovery. The candidate should be able to work closely with colleagues from medicinal chemistry, molecular pharmacology, and in vivo pharmacology to characterize the pharmacology of lead compounds and development candidates for advancement into IND-enabling studies.

  • Lead the development of bioanalytical methods to detect small/large molecule drugs and biomarkers
  • Profile ADME of drugs, including their permeability, protein/tissue binding, and clearance mechanisms
  • Analyze, interpret, and present scientific data to enable key decision-making for the projects
    Education and/or Job Experience:

    D. in biology, chemistry, pharmacology, or related discipline
  • 5+ years of industry experience developing quantitative bioanalytical methods to analyze small and large molecules for drug discovery programs
  • Knowledge of a variety of sample processing and analytical techniques, including omics-based approaches
  • Thorough understanding of PK/ADME principles and its application in drug discovery
  • High degree of technical expertise with analytical instrumentation from leading manufacturers
  • Experience managing PK studies at CROs and experience working in GLP-compliant bioanalytical labs
  • Software proficiency: MS Office, Graphpad Prism, WinNonlin
  • Excellent written and verbal communication skills
  • Ability to contribute to team goals in a fast-paced and dynamic environment

As a member of the Ardelyx team, you will play a key role in developing and bringing to market first-in-class medicines to better the lives of underserved patients. Its the patients in need that motivate and inspire us to be relentless and work hard every day. They push us to maintain a clear focus on scientific and clinical integrity with a commitment to medical innovation so that we can deliver exceptional medicines. We are different for good.

Ardelyx, Inc. is an Equal Opportunity Employer

Keywords: Ardelyx, Fremont , Senior Scientist, Other , Fremont, California

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