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Scientist II, Protein Manufacturing

Company: Thermo Fisher Scientific
Location: Fremont
Posted on: May 3, 2021

Job Description:

Scientist II, Protein ManufacturingRequisition ID: 157412BRThermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding $25 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies or increasing productivity in their laboratories, we are here to support them.US - Fremont, CAClinical Diagnostics DivisionHow will you make an impact?The Scientist II, Protein Manufacturing is responsible for manufacturing of products and completes associated documentation adhered to standard operating procedures (SOP) and current good manufacturing practices (cGMP). Works with chemicals and biologicals to manufacture or qualify material for IVD use. Participates in process improvement projects.What will you do? Manufacture protein conjugates, fragmentation of BSA by pepsin, and buffers following cGMPs.Prepare solutions from small scale (50mL) to large scale (150L)Purify protein conjugates on HPLC, FPLC and size-exclusion chromatography.Perform fragmented BSA and buffer filtrations.Perform analytical and functional testing of conjugates and fragmented BSA.Weigh, transfer, and mix required chemicals.Review in-process and completed batch records.Initiate and/or participate process improvement projects such as updating processes and/or equipment to improve efficiencies and supports business needs.Train other chemists on equipment and procedures.Write, review, or modify SOPs, work instructions and reports with guidance.Maintain and analyze lot histories for trends and discrepancies.Maintain, troubleshoot, and validate equipment as appropriate.Keep department manager updated on all issues.How will you get here?EducationApplicants should have a BA or BS degree in Biology, Molecular Biology, Biochemistry or equivalentExperience1-3 years of laboratory experience. Experience can be derived from internships or positions held post-graduation.Hands on experience with HPLC, FPLC, BioTek, and spectrophotometer is desired.Laboratory skills and knowledge of safety precautions is a plus.Experience in working with potentially hazardous chemicals and human source materials is a plus.Knowledge, Skills, AbilitiesMust have excellent math and working knowledge of the metric system (weights & volumes).Intermediate word processing and spreadsheet software skills with excellent oral and written communication skills. Good interpersonal skills.Individual must work well in a team environment and be adaptable to changes in priorities.Self-motivated, independent, and strong critical thinking.Must be organized and detail oriented to be able to prioritize own and other's work and meet business productivity metrics.Familiarity with Quality System Regulations: cGMP/GDP, ISO and IVD regulations is a plus.Manual dexterity. Must be able to lift 25 lbs routinely. May be required to lift up to 50 lbs occasionally.Our global team of more than 75,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon. For more information, please visit www.thermofisher.com .

Keywords: Thermo Fisher Scientific, Fremont , Scientist II, Protein Manufacturing, Other , Fremont, California

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