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Process Development Engineer/Associate (experience will dictate exact

Company: MabPlex USA Inc
Location: Fremont
Posted on: March 26, 2020

Job Description:

Purpose & Scope: This is an intermediate experienced engineer/associate position that will play an important role in developing stable cell lines to be used in clinical manufacturing. The position will report to the Manager of Cell Line Development. Essential Job Responsibilities:

  • Engage with business development for new client projects
  • Meet with perspective clients to understand needs
  • Propose solutions for client needs
  • Lead development of stable cell lines
  • Host cell transfection with target plasmid
  • Minipool screening and single cell cloning
  • Shake flask fed batch studies to support stability studies and top clone selection
  • Coauthor Cell Line Development report used in IND filing
  • Evaluate new technologies to improve efficiencies in cell line development
  • Evaluate new host cell systems
  • Evaluate new transfection techniques
  • Manage outsourced DNA preparation services
  • Create Development Cell Banks
  • Manage outsourced creation of Master Cell Banks
  • Assist with development of large-scale transient transfection techniques
  • Assist with the development of robust cell culture processes
  • Shake flask fed batch studies to develop optimal basal/feed media
    • OFAT/DOE screening as necessary
    • Bioreactor process optimization
    • Scale-up process optimization (up to 200 L scale)
    • Engage with Cell Culture team to evaluate new technologies
    • Engage with technology transfer of processes to manufacturing site Qualifications:
      • BS in a related science or engineering discipline with a minimum of 3 years' experience or MS with a minimum of 2 years' relevant experience
      • Proficient in cell culture and aseptic techniques
      • Good problem solving, organization, and collaborative skills are essential
      • Must be accountable and possess good communication skills (verbal and written)
      • Experience with developing stable cell lines
      • Understanding of DOE models (experience preferred)

Keywords: MabPlex USA Inc, Fremont , Process Development Engineer/Associate (experience will dictate exact, Engineering , Fremont, California

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